Click Here to return To Results

 

Effect of Interferon-B on Blood-Brain Barrier Disrupt Demonst by Contrast MRI in Relapsing-Remitting MS Ann Neurol 37:611-619, Stone,L.A.,et al, 1995 See this aricle in Pubmed Article Abstract To examine the effect of IFN-B1b on blood-brain barrier(BBB)breakdown,and to provide additional insights into the usefulness of MRI in the evolution of effectiveness of experimental treatments in MS,we used the contrast- enhanced lesion frequency of 7-month baseline MRIs compared with the enhanced lesion frequency for 6-month treatment period MRIs in 14 relapsing-remitting(RR)MS patients.Longer baselines were also available for analysis in a subset of 8 patients,as these patients had been followed by monthly MRI in a natural history study for up to 4 years prior to the current study.A significant reduction in the total or new enhancing lesion frequency on treatment inhibits the opening of the BBB in RRMS patients. This trial also illustrated the usefulness of a baseline versus treatment trial design to evaluation the effect of drug therapy in MS.

Related Tags

(click to filter results - removes previous filter) blood brain barrier interferon interferon beta 1-b MRI MRI,abnormal MRI,contrast enhanced multiple sclerosis multiple sclerosis,relapsing multiple sclerosis,treatment of treatment of neurologic disorder

Click Here to return To Results